Oral dose is rapidly absorbed and excreted by rats and man. 089-0117. Oxyde De Dimethyllaurylamine [french], 43. (1973) Unpublished data submitted by CTFA.

(1989a) Submission of unpublished data by CTFA. Please read and accept the terms and conditions and check the box to generate a sharing link.

Third Conf. 8609-4. Oral administration of a solution containing 50 mg (1-dodecyl-14C)lauramine oxide (100 uCi of 14C) to two humans resulted in excretion patterns of radioactivity similar to that of the other species studied. Lauramine Oxide at 0.1% in drinking water was not carcinogenic in rats, but at 0.1% with 0.2% sodium nitrate did increase the incidence of liver neoplasms. Lauramine Oxide at 0.1% in drinking water was not carcinogenic in rats, but at 0.1% with 0.2% sodium nitrate did increase the incidence of liver neoplasms. Ecology may be hazardous to environment.Water body should be given special attention. Detergents Ingredients Database - EU Ecolabel. It is one of the most frequently-used surfactants of this type. 1-dodecanamine, N,n-dimethl-, N-oxide, 45. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 234 (1994). Volume 5: A Review of the Literature Published during 1976 and 1977. Lauryldimethylamine oxide (LDAO), also known as dodecyldimethylamine oxide (DDAO), is an amine oxide based zwitterionic surfactant, with a C 12 (dodecyl) alkyl tail. Oak Ridge Research Institute. Radioactivity was also found in the kidneys, intestine, lungs, spleen, heart, pancreas, bone marrow, leg muscles, testes, ovaries, and whole blood. *, International Research and Development Corporation. Human cumulative irritation. (1986) Submission of unpublished data by CTFA. Thermeidics Company, Mass. (1-Dodecyl-14C)lauramine oxide (10 mg with 100 uCi of 14C) was applied to the skin of two humans to study cutaneous absorption and metabolism of lauramine oxide. Sharing links are not available for this article. For more information view the SAGE Journals Article Sharing page.

In rats, up to 40% of Lauramine Oxide applied to the skin was absorbed. Three patch application test. Acute inhalation toxicity in rats [from a formulation containing 0.3% Lauramine Oxide]. Characterization of metabolites of lauramine oxide resulted in the positive identification of only one metabolite, N-dimethyl-4-aminobutyric acid N-oxide. Cutaneously administered it is absorbed by man, rats, rabbits and mice. *, Oak Ridge Research Institute. Project no. if any. Unii-lf6bkc321j Component Syelzbgxaixkhu-uhfffaoysa-n. Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. Lean Library can solve it. Both compounds are susceptible to nitrosation and can form nitrosamines in the presence of nitrosating agents.

3029.1426.*. 60803843. *, Ricerca, Inc. (1988) Submission of unpublished data from CTFA. Washington, DC. Stearamine Oxide applied to rabbit skin at 5% did not cause irritation. You can be signed in via any or all of the methods shown below at the same time. This product could help you, Accessing resources off campus can be a challenge. Two groups of four male and one group of four female Sprague-Dawley rats were given 100 mg/kg of (methyl-14C)lauramine oxide (specific activity 1.3 mCi/g) or (1-dodecyl-14C)lauramine oxide (specific activity 1 mCi/g) orally in a metabolic study. Turan et al; Xenobiotica 11 (7): 447 (1981). Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. Ninety-two percent of the applied radioactivity was recovered from the skin of the test subjects 8 hr after dosing, and 0.1 and 0.23% of the radioactivity was recovered from the excretion products of the test subjects. (1990a) Submission of unpublished data by CTFA.

The stratum corneum contained <0.2% of the applied dose. Rabbit eye irritation (Low volume procedure) of GO955.01 [foam formulation containing 0.3% Lauramine Oxide] and GO932.01 [liquid formulation containing 0.3% Lauramine Oxide]. I have read and accept the terms and conditions, View permissions information for this article.

Report no. Human repeated insult patch test [of a formulation containing 0.3% Lauramine Oxide].

(. Washington, DC. The largest concentration of radioactivity in the tissue was found in the liver. (. The international Organisation for Economoic Co-operation and Development reported that the lowest acute oral LD50 for any amine oxide tested is 846 mg/kg body weight. Limited potential for hazards to health or the environment. (, Hill Top Research, Inc. (1989) Unpublished data submitted by CTFA. 089-0116. Toxicological Information Information on toxicological effects Acute toxicity Click the button below for the full-text content, 24 hours online access to download content.

Health issue . Safety Data Sheet (Lauramine Oxide) DATE PREPARED: 10/17/2016 Page 5 of 7 Section 11. The international Organisation for Economoic Co-operation and Development reported that amine oxides are not carcinogenic. In two human volunteers, 92% of the dose applied to the skin was recovered from the skin. Lauramine Oxide was nonmutagenic in the Ames assay, but was mutagenic after nitrosation. Study no. (1989b) Submission of unpublished data by CTFA. Can reduce the irritation of … New login is not successful because the max limit of logins for this user account has been reached. Proc. Radioactivity was detected in the liver, kidneys, testes, blood, and expired CO2. Study no. Study no. 2006. The Chemical Society. low . Foreign Compound Metabolism in Mammals. Harris Laboratories, Inc. (1987) Submission of unpublished data by CTFA. The European Union Ecolabel program reports this substance is anaerobically degradable. The rats eliminated 71 and 53% of the administered dose of (methyl-14C)lauramine oxide and (1-dodecyl-14C)lauramine oxide, respectively, in their urine, 13 and 23% as 14CO2, and 12 and 9% in their feces.

It provides high foaming and thickening properties and is stable at most pH ranges, including, stability in peroxide and hypochlorite solutions. 28-day sub-chronic percutaneous toxicity study in rabbits with G2926.02 [formulation containing 0.3% Lauramine Oxide]. N,n-dimethyldodecylamine N-oxide Solution, 104.

Access to society journal content varies across our titles. Contact us if you experience any difficulty logging in. The distribution of radioactivity was essentially the same as that seen in rats given oral doses of lauramine oxide. Sixty-seven percent of the total radioactivity was eliminated in the urine, 8% was expired as I4CO2, and 6% was eliminated in the feces within 24 hr. Reproductive Toxicity . [Acute oral toxicity study of a 20% dilution of Lauramine Oxide]. (1984) Cosmetic product formulation data: ingredients used in each product category. Human repeated insult patch test. Likely hazards to health or the environment.

(1992) Frequency of use data. Test no. *, In Vitro Alternatives, Inc. (1992b) Submission of unpublished data by CTFA. *, In Vitro Alternatives, Inc. (1992a) Submission of unpublished data by CTFA.

London: The Chemical Society, 1979., p. 501. Cosmetic, Toiletry and Fragrance Assoc, Inc. Rabbit eye irritation (Low volume procedure) [of 0.3% Lauramine Oxide]. Rabbit eye irritation study [of 5% Stearamine Oxide]. Peak tissue levels in rats occur within 1 hr.

(1990b) Submission of unpublished data by CTFA. ... LAURAMINE OXIDE can be found in 271 products. Simply select your manager software from the list below and click on download. At 0.3%, Lauramine Oxide was not a sensitizer in clinical studies. Cutaneous Toxicity, Washington, DC, May 16-18,1976.

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 191-1448. Lauramine Oxide is an Amine N-oxide, an active component primarily found in shampoo, bubble bath and hand soap thanks to its foam building properties . Aqueous (methyl-14C)lauramine oxide (10 mg containing 1.3 mCi/g) was applied to the skin of four Sprague-Dawley rats to test metabolism and absorption of the compound.

N,N-dimethyl-4-aminobutyric acid and its N-oxide accounted for 28, 28 and 23% in man, rats and rabbits, respectively. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box.

PB85-122661.

Study no. (. By continuing to browse Few/no known or suspected hazards to health or the environment, Limited potential for hazards to health or the environment, Some potential for hazards to health or the environment, Likely hazards to health or the environment, Potentially significant hazards to health or the environment. *, Industrial Biology Laboratories, Inc. (1963) Unpublished data submitted by CTFA.

Up and down procedure for estimating acute oral toxicity (LD50) in rats of GO955.01 [foam formulation containing 0.3% Lauramine Oxide] and GO932.01 [liquid formulation containing 0.3% Lauramine Oxide]. The email address and/or password entered does not match our records, please check and try again. At a concentration of 30%, Lauramine Oxide produced severe dermal reactions in rabbits, but at 0.3% only slight to moderate erythema with slight edema, Assuring, and slight to moderate epithelial desquamation were found. NTIS No.

Martha Stewart Clean Carpet Stain Remover, Planet Delicate Laundry Wash, Hypo-Allergenic, Babyganics Floor Cleaner Concentrate, Fragrance Free, biokleen Natural Dish Liquid, Citrus Essence, Puracy Natural Laundry Detergent, Free & Clear, Earth Friendly Products ECOS Dishmate Dish Soap, Free & Clear, Earth Friendly Products ECOS Dishmate Dish Soap, Lavender, Total Home Earth Essentials Liquid Dish Soap, Eucalyptus Lemon, Dapple Baby Laundry Detergent Strips, Fragrance-Free, Total Home Earth Essentials Liquid Dish Soap, Fragrance Free. Food and Drug Administration. 89-0043-73D. Acute oral toxicity (LD50) [of 0.3% Lauramine Oxide] in rats. Modification in voluntary filing of cosmetic product ingredient and cosmetic raw material composition statements, N-nitroso-N-methyldodecylamine and N-nittoso-N-methyltetradecylamine in hair-care products, Studies of in vitro cell transformation and mutagenicity by surfactants and other compounds, The carcinogenic effect of nitrosomethyldodecylamine in European hamsters, Induction of urinary bladder tumors in rats by administration of nitrosomethyldodecylamine, Induction of carcinogenesis in Fischer rats by methyl- alkylnitrosamines, Carcinogenesis by exposure to nitrites and amines, Induction of tumors in rats by feeding nitrosatable amines together with sodium nitrite, Utility of amine oxides in oil/water cosmetic systems, The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine, Dermatitis from Ammonyx LO, a constituent of a surgical scrub, The acute toxicity of three oil dispersants, The absorption, tissue distribution, and excretion of dodecyldimethylamine oxide (DDAO) in selected animal species and the absorption and excretion of DDAO in man, Toxicity and carcinogenicity of N-nitroso-compounds, Comparing dodecylmethylamine oxide with stearyldi-methylamine oxide, Oil spill clean-up: the effect of three dispersants on three subtropical/ tropical seagrasses, A comparison of the elimination and biotransformation of dodecyldi- methylamine oxide (DDAO) by rats, rabbits, and man, Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide, https://doi.org/10.3109/10915819409141001, Amended Final Report of the Safety Assessment of Cocamidopropylamine Oxide1.



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